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Dual-acting Antidepressants venlafaxine Effexor R. Please consult with or refer to the Evidence of Coverage document. Nefazodone requires prior authorization and is not included as a required agent; however, a prior trial of nefazodone will be sufficient for approval of a step therapy agent.

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Bupropion is an antidepressant, which has recently been promoted for the treatment of bipolar depression, because of its lower potency to induced switch. However, due to its dopamine enhancing effect, it has been reported to induce psychosis and perceptual changes. Some of the case report which have reported development of psychosis with sustained release Bupropion, it has been reported in the background history of over dosage or substance abuse.

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